Doctor's Best - Brain Magnesium with Magtein™ 50 mg

Doctor's Best - Brain Magnesium with Magtein™ 50mg supplies magnesium l-threonate (Magtein™), a unique magnesium compound for delivering magnesium to the brain. Magnesium is essential for the brain connections (synapses) that facilitate learning, memory, attention, and all other brain functions. The l-threonate salt extends the action of magnesium. In preclinical studies, Magtein™ performed better than other magnesium compounds for synapse support. Best Brain Magnesium is a breakthrough for brain health.

Benefits:
•Unique delivery of magnesium into the brain
•Vital for memory, learning, concentration
•Promotes stability and adaptability of brain connections (synapses)
•Supports mood and other aspects of cognitive health

Unique delivery of magnesium into the brain
The MagteinTM magnesium-L-threonate (MgT) in Best Brain Magnesium, in contrast to other magnesium compounds, has been shown to effectively raise magnesium levels in the brain, according to animal research carried out with MgT. The researchers who discovered the advantages of increased brain magnesium on memory in rats first had to figure out which oral form of magnesium would best be able to elevate brain magnesium. They used four commercially available Mg2+ compounds (Mg2+ is the most abundant divalent cation, or positively charged ion, in living cells) and developed two new preparations, one of which was MgT. Of the six forms studied, only two had higher bioavailability—and of those two, only MgT was able to enhance memory.

Promotes stability and adaptability of synapses
Magnesium is a cofactor for numerous enzymes that control nerve cell functions and synapse integrity. Synapses are the points where nerve cells make close contact with each other via their cell membranes to exchange information. The movements of ions such as Mg2+ across the nerve cell membranes can change as we age, adversely affecting cellular excitability, chemical transmitter release, and synaptic plasticity (synapse adaptability). The ability to store new information in nerve cell networks depends on the density and strength of the synapses, and their capacity to adapt to changing information inputs (synaptic plasticity). Additionally, loss of synapse density is correlated with age-dependent memory decline in rats. Numerous animal trials have been performed to measure the effect of magnesium-L-threonate on cognitive outcomes. In a recent investigation, feeding MgT to raise brain magnesium led to significant enhancement of spatial and associative memory in both young and old rats.

Memory and learning decline with age, yet magnesium-L-threonate has been shown to slow this decline in mice. At the cellular level, MgT supported the integrity of synapses in the hippocampus, frontal cortex, and other regions of the brain. Magnesium-L-threonate hasn’t yet completed a clinical trial, but human studies have evaluated the effects of magnesium on human memory performance. For example, in a study of 71 men and women higher blood levels of magnesium were associated with superior cognitive function, as measured by clinical ratings and scales