MD Nutritionals Estro-Sense

Estro-Sense® can assist female health conditions associated with oestrogen dominance. It is indicated in the relief of menopausal symptoms and medically diagnosed cyclical mastalgia and fibrocystic breast disease.
Estro-Sense® features Indolplex®, a unique and highly absorbable diindolylmethane as found in cruciferous sources with demonstrated clinical activity.
Indolplex® assists the favourable metabolism of oestrogen down the 2-hydroxylation pathway.A beneficial shift in metabolism can help maintain healthy oestrogen ratios and reduce the symptoms of oestrogen dominance. This is particularly important to assist breast health.
The active 2-hydroxyoestrone metabolites are considered the ‘good’ oestrogens.Whereas the 4-hydroxyoestrone and 16-alpha-hydroxyoestrone metabolites are often termed the ‘bad’ oestrogens. Improved metabolism of available oestrogen allows healthy expression of this key hormone.
Indolplex® may assist breast health in women. This action is supported by iodine, selenium and vitamin D3.
Fucus vesiculosus (Bladderwrack) is a rich source of iodine. Mild iodine deficiency is common in Australia.
Iodine is a well studied mineral to help relieve the symptoms of fibrocystic breast disease. The breast tissue concentrates iodine with an iodine deficiency associated with the development of breast health issues.
Iodine is an essential element for the synthesis of triiodothyronine (T3) and thyroxine, and is therefore required for normal thyroid function. Healthy thyroid activity assists favourable hydroxylation of oestrogen.
Iodine deficiency leads to an increased sensitivity of breast tissue to oestrogen. Iodine may also have a protective effect on the breast tissue by modulating oestrogen pathways.
The incidence of benign and malignant breast disease is low in Japan when compared to the United States and other western countries. It is suggested that a lower incidence is attributed to a higher intake of iodine from the traditional Japanese diet. Seaweed and seafood consumption is a key source of iodine and is widely used in sushi, soups, salads and condiments.
Vitamin D3 (cholecalciferol) is the naturally occurring form of vitamin D. The biological effects extend far beyond controlling mineral metabolism. Vitamin D3 is now considered a ‘repair and maintenance’ pro-hormone that targets a wide variety of tissue.Vitamin D3 supports overall health, including a healthy immune system. In Australia, the prevalence of vitamin D deficiency is widespread despite the abundance of sunshine.
Studies support an association between iodine and vitamin D3 with improved breast health. A deficiency of vitamin D is associated with an increased risk of both breast and ovarian disorders.
Selenium is an essential micronutrient fundamental to health. It is a necessary component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems and immune function.